SYNVISC®

What Is Synvisc Injection?

Synvisc injection is a treatment designed to relieve pain and improve mobility in individuals suffering from osteoarthritis. This injectable gel, made from hylan polymers derived from rooster combs, mimics the properties of natural synovial fluid, which lubricates joints.

When injected into the knee joint, Synvisc acts as a cushion and lubricant, helping to reduce friction between bones, alleviate pain, and enhance joint function. It is particularly beneficial for patients who have not found sufficient relief from other conservative treatments, such as physical therapy or pain medications.

What Is Synvisc Injection Used for?

Synvisc is an FDA-approved injectable treatment specifically designed for relieving knee pain associated with osteoarthritis. It is intended for patients who have not experienced sufficient relief from conservative non-pharmacologic therapies and simple analgesics, such as acetaminophen.

Who Is the Manufacturer of Synvisc Injections?

Synvisc injections are manufactured by Genzyme Corporation, based in New Jersey.

Benefits and Results of Using Synvisc Injections 

• Provides significant and long-lasting pain relief 
• Improves symptoms associated with knee osteoarthritis
• Proven to be more effective than saline injections or fluid removal in clinical studies
• Offers relief for patients who haven’t responded to other treatments

Synvisc Injection Main Ingredients and Device Properties

Synvisc injection is made up of hydrated hylan A and B polymers derived from rooster combs. These polymers are chemically cross-linked to improve viscosity and elasticity, resulting in a viscoelastic injectable gel that closely resembles natural synovial fluid. Each syringe contains hylan, along with sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate hydrate, and sterile water for injection.

Accessories or Items Included

Synvisc is supplied in a 2.25 mL glass syringe, containing a 2 mL dose of hylan G-F 20. The product also comes with traceability labels and a product pamphlet. 

Storage Conditions

Store in original packaging (protected from light) at room temperature below 86°F (30°C). Do not freeze.

Mode of Administration

Synvisc is administered through an intra-articular injection, typically once a week for three weeks, with each injection spaced one week apart. Prior to each injection, synovial fluid or joint effusion should be removed from the knee. An 18- to 22-gauge needle is used for this process. To minimise leakage during administration, the tip cap should be twisted before being removed, and the needle must be tightly secured on the syringe.

The entire 2 mL dose is injected into one knee only. Synvisc is intended solely for injection into the knee by a healthcare professional and has not been tested for pain relief in other joints.

Post-Treatment Care

After the injection, patients should avoid strenuous activities, including high-impact sports and prolonged weight-bearing activities, for about 48 hours. Patients should consult their physician before resuming these activities.

How Long Do Synvisc Effects Last?

The effects of Synvisc injections can last up to 6 months, providing significant pain relief and improved knee function.

Potential Side Effects

After receiving Synvisc injections, some patients may experience temporary pain, swelling, or fluid build-up (effusion) in the treated joint. Significant swelling can cause discomfort, and patients should consult a doctor if this occurs.

The most common side effects include pain, swelling, and joint effusion in the injected knee. Other possible reactions are joint stiffness, warmth, injection site pain, arthritis, and gait disturbance. Rest, ice, or pain relievers may help manage these symptoms.

If significant pain or swelling occurs, patients should contact their healthcare provider for further evaluation. 

In rare cases, allergic reactions may occur, with symptoms like rashes, itching, swelling of the face, fast heartbeat, nausea, and difficulty breathing. In very rare instances, joint infections or low platelet counts have been reported.

Contraindications for the Treatment

Synvisc should not be administered to patients with:

• Known hypersensitivity or allergies to hyaluronan or sodium hyaluronate products
• Knee joint infections or skin diseases at the injection site

The safety and effectiveness of Synvisc injections has not been established in pregnant or lactating women, nor patients under 21 years of age. 

Who Can Buy Synvisc Injections and Where?

Synvisc injections are available only to licensed healthcare professionals, such as doctors and pharmacists. They can be purchased from authorized medical distributors or online pharmacies specialising in medical supplies. It is important to ensure Synvisc One is obtained from a reliable source to guarantee product safety and efficacy. Buy Synvisc orthopedic injections online on Nu Derma Supply.