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Nucleofill dermal filler is a cutting-edge biostimulant gel made from natural polynucleotides and characterised by high viscosity, designed for skin rejuvenation and protection. As an anti-aging treatment, Nucleofill enhances skin elasticity and firmness while helping to prevent wrinkles. Promoitalia’s flagship line, Nucleofill, comprises four specialised products, each tailored to address specific skin concerns.

Buy Nucleofill online today.

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Buy Nucleofill to Lift, Protect and Hydrate the Skin

Renowned for its advanced cross-linked hyaluronic acid technology, Nucleofill is a premier choice for aesthetic treatments, including wrinkle reduction and lip augmentation. This line of dermal fillers offers effective, non-surgical solutions for individuals seeking facial rejuvenation.

What Is Nucleofill?

Nucleofill is a specialised range of skin boosters designed to achieve various skincare goals by acting on three levels: lifting, antioxidant protection, and hydration. Unlike typical skin boosters, Nucleofill does not contain hyaluronic acid. Instead, it uses high molecular weight polynucleotide chains to protect and rejuvenate the skin. These polynucleotides stimulate type 1 collagen production and transform fibroblasts into myofibroblasts, enhancing skin structure and hydration.

The unique biochemical properties of these polynucleotides grant the product high viscoelasticity and a strong ability to bind water, providing intense moisture and deep hydration. Additionally, Nucleofill delivers a potent bio-stimulating effect, encouraging skin regeneration through a three-way mechanism.

Who Is the Manufacturer of Nucleofill?

Nucleofill is produced by Promoitalia, a renowned Italian company specialising in advanced aesthetic treatments.

What Are The Main Ingredients of Nucleofill?

Nucleofill products are composed of polymerized polynucleotides in a transparent gel form, derived from salmon cells.

In aesthetic medicine, polynucleotides extracted from salmon DNA are used due to their remarkable compatibility with human skin and their potent hydrating and tissue-regenerating abilities. 

How Does It Work?

Nucleofill is manufactured using the unique PDRN complex from salmon cells, undergoing a multi-stage purification process. PDRNs are DNA fragments that penetrate cells and repair molecular damage. These polynucleotides are safe, natural, and highly effective.

Polynucleotides activate receptors on skin fibroblasts, transforming them into myofibroblasts. This boosts the production of type I collagen and elastin, tightening and lifting the skin. The product eliminates free radicals and provides antioxidant protection, as well as bind water, ensuring long-term hydration of the extracellular matrix. This process helps the skin regenerate, thicken, and strengthen, resulting in improved skin tone, reduced wrinkles, and enhanced moisture and elasticity.

What Is Nucleofill Used for?

Nucleofill is a range of high-viscosity biostimulating gels, formulated with natural polynucleotides to protect and rejuvenate the skin. These injectables offer four distinct types of skin stimulation:

  • Skin regeneration
  • Deep cleansing through increased blood circulation and removal of free radicals
  • Provides deep and sustained intracellular hydration
  • Improves skin firmness and corrects contours

Nucleofill is indicated for all skin types, regardless of their maturity and it can help with more than just signs of aging, as it helps addresses various skin concerns, including dehydrated skin, signs of exposure to oxidative stress (pollution, sun, tobacco, lifestyle), scars, stretch marks and more. 

Nucleofill Product Range

The Nucleofill range offers specialised products designed for various skin concerns and rejuvenation goals:

  • Nucleofill Medium: Focuses on deep cell regeneration, strengthening skin turgor, moisturising, and stimulating collagen production. Its cellular-level action ensures long-lasting rejuvenation effects.
  • Nucleofill Strong: Provides deep skin renewal and bio-restructuring with lifting and antioxidant properties. This innovative treatment also offers intense hydration for the skin.
  • Nucleofill Touch: Reduces the appearance of expression wrinkles, giving the skin a fresher and more youthful look.
  • Nucleofill Soft Plus: Specifically formulated for the delicate eye area, it smooths wrinkles, lightens dark circles, tightens the skin, and increases its density.
  • Nucleofill Medium Plus Hair: Formulated to stimulate hair growth and prevent hair loss. It is particularly effective in treating androgenetic alopecia and various forms of hair weakening.

Benefits of Using Nucleofill

Nucleofill provides a comprehensive solution for achieving smoother, more defined, and naturally rejuvenated skin.  Here are some of the key advantages:

  • Smoothens wrinkles, nasolabial folds and marionette lines, providing better skin texture
  • Enhances and defines facial contours, improving overall facial harmony (particularly effective for areas such as the cheekbones, chin, and jawline)
  • Stimulates dermal remodelling over time
  • Treatments are convenient and quick, and depending on the desired result, can be completed in a single session
  • The results are subtle, enhancing natural features without looking overdone

How Long Does Nucleofill Last?

Typically, the results last from three to six months. After that, maintenance treatments may be recommended to sustain the desired results over time. 

Potential Side Effects of Nucleofill

As with any dermal filler treatment, there are potential side effects and risks to consider. Common and temporary adverse effects may include:

  • Temporary redness at injection sites
  • Swelling
  • Bruising
  • Tenderness

More serious complications are rare but can occur, so it’s essential to follow post-treatment care instructions and seek prompt medical attention if any concerning symptoms arise.

Contraindications for the Treatment

Nucleofill products are entirely natural and safe, and they do not contain substances with sensitising potential. Still, specific contraindications may make it unsuitable for some patients that have:


  • Systemic diseases
  • Epilepsy
  • Blood clotting problems
  • To take anticoagulants
  • Tendency to keloid formation
  • Temporary inflammation
  • Damage to the surface of the skin
  • To breastfeed or are pregnant.

Who Can Buy & Where to Buy Nucleofill Products?

Nucleofill products are available for purchase by licensed medical professionals, including dermatologists, cosmetic surgeons, and aesthetic practitioners. These professionals use Nucleofill to provide advanced skin rejuvenation treatments to their patients.

When purchasing Nucleofill products online, it is crucial to choose official suppliers to ensure the product’s authenticity and safety. Official suppliers, like Nu Derma Supply, guarantee that you receive genuine Nucleofill products that meet the highest standards of quality and efficacy.

Our website is intended solely for people who use medical devices, such as dermal fillers, as professionals. It may contain product advertisements targeted only at such people. To enter Nu Derma Supply, please confirm that you are such a person (e.g. a medical professional, cosmetologist, service technician, etc.).