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Refine+ Ultra Soft



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Refine+ Filler Ultra Soft is a skin booster, a type of dermal filler that is designed to provide immediate hydration and improve the overall quality of the skin. It contains a weakly cross-linked hyaluronic acid with a concentration of 12 mg/mL, which is a smooth, non-animal, stabilized, and bio-resorbable substance that is well-tolerated by the body.

With its special bio-resorbable property, Refine+ Filler Ultra Soft not only corrects minor facial skin depressions but also stimulates the production of new collagen in the skin. This results in improved skin texture and tone, reduced appearance of fine lines and imperfections, and an overall youthful and rejuvenated appearance. The product is suitable for all skin types and can be used to rejuvenate the face, neck, or hands.


Fine wrinkles

For the treatment of fine wrinkles, inject small amounts of the product into the targeted areas using a fine needle. It is important to inject the filler at the appropriate depth, depending on the location of the wrinkles, and to use the smallest effective amount of filler. Avoid overfilling the area, as this can lead to an unnatural appearance.

General improvement of skin quality

To improve the overall quality of the skin on the face, neck, cleavage, and hands, use a combination of superficial and deeper injections with Refine+ Filler Ultra Soft. This can help to hydrate the skin, restore lost volume, and stimulate collagen production. Inject the filler in small amounts in a grid pattern, and use a combination of linear and fan-shaped injections to achieve a natural-looking result.

Flabby and dry skin

For patients with flabby and dry skin, use Refine+ Filler Ultra Soft to add volume and hydration to the targeted areas. Inject the filler in a series of small, superficial injections to distribute it evenly throughout the treatment area. For best results, combine filler injections with other treatments that can improve skin elasticity, such as radiofrequency or ultrasound therapy.

To maintain the effect of other aesthetic medicine treatments

Refine+ Filler Ultra Soft 1

Refine+ Filler Ultra Soft can be used to maintain the results of other aesthetic medicine treatments, such as botulinum toxin injections or laser resurfacing. Inject the filler in small amounts into the targeted areas to restore volume and smooth out any remaining wrinkles or lines.

Elimination of photo-damage and acne scars

For the treatment of photo-damage and acne scars, use Refine+ Filler Ultra Soft to add volume to the targeted areas and smooth out any uneven texture. Inject the filler in a series of small, superficial injections to distribute it evenly throughout the treatment area. For best results, combine filler injections with other treatments that can improve skin texture, such as chemical peels or microneedling.

Stimulation of collagen production

The product can also be used to stimulate collagen production in the skin. Inject the filler in a series of small, superficial injections to trigger the body’s natural collagen production process. Repeat the treatment at regular intervals to maintain the desired effect.

How does the stimulation of collagen using skin boosters work?

Hyaluronic acid (HA) can stimulate collagen production through a few different mechanisms. Here are some of the ways that HA can help to promote collagen synthesis:

Activation of fibroblasts: Fibroblasts are cells that play a key role in collagen synthesis. Hyaluronic acid can activate these cells, leading to an increase in collagen production.
Increased cell proliferation: Hyaluronic acid can stimulate cell proliferation, which can help to increase the number of cells involved in collagen synthesis.

Improved tissue hydration: Hyaluronic acid is a natural moisturizer that can help to hydrate the skin and improve its overall health. When the skin is well hydrated, it is more able to support the production of collagen.
Protection against free radicals: Free radicals are unstable molecules that can damage cells and tissues, including collagen. Hyaluronic acid has antioxidant properties that can help to protect against free radical damage, thereby promoting collagen synthesis.

Overall, the ability of hyaluronic acid to stimulate collagen production depends on the specific product being used, as well as factors such as the patient’s age and skin condition. It’s important to note that while hyaluronic acid can help to promote collagen synthesis, it is not a replacement for collagen itself. Rather, the goal is to support the body’s natural collagen production processes and help to maintain healthy, youthful-looking skin.

It’s important to note that the specific technique and amount of filler used will vary depending on the individual patient’s needs and goals, as well as the location and severity of the targeted area. Always consult with the patient to fully understand their desired outcome and create a treatment plan that is tailored to their specific needs. Additionally, follow standard safety protocols when administering any dermal filler, and ensure that the patient is fully informed of any potential risks and side effects associated with the treatment.


To ensure a safe treatment with Refine Filler products, it is essential to assess patients’ medical history and suitability. The use of the Refine+ Filler Soft is contraindicated in the following cases:

  • Allergy to components present in the product
  • Pregnancy or breastfeeding
  • Injection in areas with skin problems (infection, inflammation)

The pack contains one graduated pre-filled syringe for 1 ml and two 30G needles, making it easy and convenient to use. For best results, we recommend one session per week, four times in total. The solution of Refine+ Filler Ultra Soft has a pH of 7, which is close to the natural pH of human skin, making it safe and well-tolerated by the body.

It is important to note that this product must be administered only by a professional authorized to inject hyaluronic acid-based filling products.

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